If you have a physical console, you can play the ISO by burning it to a DVD or loading it via a hard drive using Free McBoot or OPL (Open PS2 Loader).

With Naruto Shippūden: Ultimate Ninja Storm 2 and 3 available on PC, why bother with the PS2 version?

The European version (PAL) already has English text, but it runs at 50FPS (slower). The Japanese version (NTSC-J) runs at 60FPS (smoother) but is in Japanese.

To get the best experience (60FPS + English):

Searching for "Naruto Ultimate Ninja 6 PS2 ISO" leads you into the gray/black market of ROM sites. Here is what to expect:

Pros of downloading:

Cons & Major Risks: