Follow these steps in order. Do not skip.
An unstable physical connection (cable older than 6 months, USB 3.0 port, extension hub) introduces noise into the data line. SPD protocol has zero error correction for handshake packets. One dropped bit = R400001. spd flash tool r400001
Based on my debugging, R400001 indicates a communication timeout between the programmer (e.g., a CH341A, Bus Pirate, or dedicated SPD programmer) and the target memory module’s EEPROM. In plain English: the tool sent a command, but the memory module didn’t respond in time. Follow these steps in order