This is where most players fail. The Insect Prison remake introduces Airborne Units (Wasps and Mosquitoes).
The Updated Mid-Game Defense:
The "Updated" Meta Combo (Patch 2.1.2): Fire Ant + Acid Sprayer. The Fire Ants cause "Panic" (enemies run backward). The Acid Sprayer leaves a puddle that lasts 8 seconds. When a panicked enemy runs back through the acid, they take double tick damage. This combo clears Wave 20-25 instantly. insect prison remake guide updated
The remake adds three new bosses not in the original game: This is where most players fail
The vents are no longer silent. You must move only when the ceiling drips (every 4 seconds). The "Updated" Meta Combo (Patch 2