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FPRE080 provides a fast, accurate, and thermodynamically grounded solution for RNA secondary‑structure prediction. Through minimal free‑energy modeling enhanced by parameter pruning and stochastic beam search, it delivers state‑of‑the‑art performance on a rigorously curated benchmark (Dataset 015958) while requiring modest computational resources. The open‑source implementation (GitHub: mina-kitano/fpre080) invites community adoption and further development.


Mina Kitano (北野未奈) is a Japanese AV actress who debuted around 2020 and quickly gained popularity. Known for her natural performances and versatile acting, she has worked with studios like Fitch, Madonna, Premium, and SOD. Her filmography includes titles covering drama, romantic scenarios, and more explicit themes, always produced within Japan’s regulated adult video industry.

All matrix‑based operations (pair‑energy tables, beam updates) are offloaded to an NVIDIA RTX 4090 via a custom CUDA kernel that:

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  • Accurate prediction of RNA secondary structure remains a cornerstone of functional genomics, drug design, and synthetic biology. We present FPRE080, a novel computational pipeline that couples a refined thermodynamic model with a fast stochastic sampling algorithm to locate the minimal free‑energy (MFE) conformation of medium‑length RNAs (50‑300 nt). Using a curated benchmark (Dataset 015958) comprising 1 200 experimentally validated structures, FPRE080 achieves a mean sensitivity of 86 % and positive predictive value of 84 %, surpassing state‑of‑the‑art tools (RNAfold, CONTRAfold, and LinearFold) while requiring only 30 % of the runtime. The method is freely available under an open‑source license and can be integrated into existing pipelines for high‑throughput RNA analysis.


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    FPRE080: A Minimal‑Free‑Energy Framework for Predicting RNA Secondary Structures
    by Mina KitanoDataset ID: 015958


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